Pyrimidine, 2-chloro-4-methoxy-
2-Chloro-4-methoxypyrimidine
CAS: 22536-63-6
Molecular Formula: C5H5ClN2O
Pyrimidine, 2-chloro-4-methoxy- - Names and Identifiers
| Name | 2-Chloro-4-methoxypyrimidine |
| Synonyms | 2-Chloro-4-methoxypyrimidine 2-CHLORO-4-METHOXYPYRIMIDINE 2-Chloro-6-methoxypyrimidine 2-Chloro-4-methoxy- pyrimidine 2-Chloro-4-methoxy-1,2-diazine Pyrimidine, 2-chloro-4-methoxy- Pyrimidine, 2-chloro-4-methoxy- (6CI,8CI,9CI) |
| CAS | 22536-63-6 |
| InChI | InChI=1/C5H5ClN2O/c1-9-4-2-3-7-5(6)8-4/h2-3H,1H3 |
| InChIKey | BDXYNMVQMBCTDB-UHFFFAOYSA-N |
Pyrimidine, 2-chloro-4-methoxy- - Physico-chemical Properties
| Molecular Formula | C5H5ClN2O |
| Molar Mass | 144.56 |
| Density | 1.292±0.06 g/cm3(Predicted) |
| Melting Point | 54-57 °C (lit.) |
| Boling Point | 96-97 °C(Press: 18 Torr) |
| Flash Point | >230°F |
| Vapor Presure | 0.012mmHg at 25°C |
| Appearance | Crystalline Powder |
| Color | White to yellow |
| pKa | 0.07±0.20(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Refractive Index | 1.52 |
| MDL | MFCD00194055 |
Pyrimidine, 2-chloro-4-methoxy- - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| HS Code | 29335990 |
Pyrimidine, 2-chloro-4-methoxy- - Reference Information
| Use | 2-chloro-4-methoxypyrimidine is an organic intermediate, which can be used as a raw material with 2, 4-dichloropyrimidine It is obtained after nucleophilic substitution with sodium methoxide or potassium methoxide. It can be used as a pharmaceutical intermediate for the preparation of HIV prevention drugs and inhibitors of Bruton's tyrosine kinase. |
| Preparation | Add NaOMe(2.84g,52.5mmol) in MeOH(20mL) dropwise to a solution of 2, 4-dichloropyrimidine (7.5g,50mmol) in MeOH(20mL) at 0°C. The reaction mixture was stirred at 0°C for 2h. The reaction mixture is concentrated in a vacuum to obtain a crude product. Pour the crude product into 150mL of water. The aqueous phase was extracted with EtOAc(100mL). The organic layer was dried with Na2SO4 and concentrated in vacuum to give 2-chloro-4-methoxypyrimidine in a pale yellow solid (5.9g, yield: 82%). |
Last Update：2024-04-09 02:00:01
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